Vishal Bhargava, Dr. Ashutosh Mishra
Vol. 1, Jan-Jun 2016
Abstract:
Risperidone, an antipsychotic drug, is commonly used for treating schizophrenia and bipolar disorder. However, its therapeutic efficacy is often compromised due to its short half-life and the necessity for frequent dosing. This study aims to develop a controlled-release matrix tablet of risperidone using a novel polymeric blend of Methocel® (hydroxypropyl methylcellulose, HPMC) and Ethocel® (ethyl cellulose) to enhance its in vitro drug release and bioavailability. Various formulations were prepared, characterized, and evaluated for their physicochemical properties, drug release profiles, and bioavailability. The findings indicate that the polymeric blend significantly influenced the drug release kinetics and improved the bioavailability of risperidone.