Dr. Kanhaiya Singh, Rashmi Kiran
Vol. 18, Issue1, Jul-Dec 2024
Abstract:
This randomized controlled trial (RCT) investigated the therapeutic potential of Neem (Azadirachta indica) in managing Type 2 Diabetes Mellitus (T2DM) and food addiction. Conducted over six months in Patna, Bihar, the study included 50 diabetic patients aged 30–60 years with a history of food cravings. Participants were randomly assigned to the Neem group (500 mg Neem extract twice daily) or the placebo group, both following a standard diabetic diet. Metabolic and behavioral outcomes were assessed at baseline and after six months. The Neem group showed significant reductions in fasting blood glucose (FBG) by 22.3%, postprandial blood glucose (PPBG) by 26.4%, and HbA1c by 21.2%, compared to minimal improvements in the placebo group (2.9%, 4.4%, and 3.6%, respectively). Insulin resistance, measured via HOMA-IR, decreased by 39.6% in the Neem group, while the placebo group achieved only a 6.4% reduction. The Neem group exhibited a 42.8% reduction in Yale Food Addiction Scale (YFAS) scores, indicating decreased food cravings, compared to 6.6% in the placebo group. The findings suggest that Neem extract significantly improves glycemic control, reduces insulin resistance, and mitigates food addiction tendencies, offering dual metabolic and behavioral benefits. Neem’s efficacy highlights its potential as a natural adjunct therapy for T2DM management.
DOI: http://doi.org/10.37648/ijrmst.v18i01.011