Dr. Sahar Muhssin Muhammad M.B.Ch.B., D.G.O., Dr.Samira A Muhsin M.B.Ch.B., D.G.O.
Vol. 7, Jan-Jun 2019
Abstract:
Background: Infertility is failure to achieve pregnancy after one year of un protected intercourse. In approximately 40% of infertile couples, the male partner is either the sole or a contributing cause of infertility. A severe defect of spermatogenesis including reduced sperm count, motility and many sperm with abnormal morphology, will probably always be relevant. However, mild defects may only become relevant as the age and the duration of infertility increases. Objectives: Evaluate the relationship of age and duration of infertility with sperm parameters and correlate them with IUI outcome. Patients, materials and methods: One hundred thirty-five infertile couples were participated in this study where the male partners subjected to in vitro sperm preparation and activation, while the female partners were normal and had ovarian stimulation program. In vitro sperm activation was performed using two different methods, the centrifugation swim-up technique and density gradient technique with. The mean ages of infertile males were 35.614±0.539 years with a range from 22 to 52 and the mean duration of infertility was 6.113±3.75 years with a range from 1 to 20 years. Both groups were subjected to IUI. Results: Lowest sperm concentration and motility with age group (> 50) years. However; best results in this study regarding total sperm motility was with duration of infertility (3-4) years and the lowest total sperm motility with duration (>10) years. Regarding IUI, the highest IUI outcome was with age group (30-39) years and with duration of infertility (<2) years (25%). Conclusion: This study concluded that sperm parameters and IUI outcome inversely correlated with duration of infertility. Also better sperm parameters regarding concentration, motility, morphology and IUI outcome was with young age group. Since the sperm parameters and IUI outcome decline with age and with longer duration of infertility as shown by the results of this study so better to interfere with IUI in couples with duration of infertility less than two years.